阿托伐他汀联合丹红注射液治疗椎-基底动脉硬化致脑供血不足的效果分析

Analysis on efficacy of atorvastatin combined with Danhong injection in treatment of cerebral insufficiency caused by vertebral-basilar arteriosclerosis

目的探讨阿托伐他汀与丹红注射液联合治疗椎-基底动脉硬化致脑供血不足的临床疗效。方法收集2012年1月~2013年12月,我院收治的椎-基底动脉硬化致脑供血不足患者64例,随机分为观察组与对照组,各32例。两组均以常规西医治疗,对照组加用阿托伐他汀和盐酸氟桂利嗪治疗,观察组加用阿托伐他汀和丹红注射液治疗,比较两组的临床疗效。结果观察组的总有效率为100%,显著高于对照组的62.5%（P〈0.05）;治疗后观察组的左侧椎动脉、右侧椎动脉及基底动脉的最大血流速度均显著高于对照组（P〈0.05）;观察组的不良反应率为3.13%,显著低于对照组的12.50%（P〈0.05）。结论阿托伐他汀与丹红注射液联合治疗椎-基底动脉硬化致脑供血不足可有效改善脑部血供,缓解临床症状,提高临床疗效,不良反应少,值得推广应用。

Objective To investigate the clinical efficacy of atorvastatin combined with Danhong injection in treatment of cerebral insufficiency caused by vertebral-basilar arteriosclerosis. Methods 64 patients with cerebral insufficiency caused by vertebral- basilar arteriosclerosis in our hospital between January 2012 and December 2013 were collected and randomly divided into observation group and control group32 cases in each group.The two groups received conventional Western treatment,the control group added atorvastatin and flunarizine hydrochloride therapy,the observation group added atorvastatin and Danhong injection therapy on the basis of the control group, the clinical efficacy of two groups were compared. Results The total effective rate in observation group was 100%,significantly higher than the 62.5% in the control group（P〈0.05）;The maximum flow velocity of left vertebral artery,right vertebral artery and basilar artery in observation group was significantly higher than the control group（P〈0.05）;Adverse reaction rate of observation group was 3.13%,significantly lower than 12.50% in the control group（P〈0.05）. Conclusion Atorvastatin combined with Danhong injection ind treatment of cerebral insufficiency caused by vertebral-basilar arteriosclerosis can effectively improve the blood supply of the brain,relieve symptoms and improve clinical efficacy,has less adverse reaction, should be widely applied.