围孕期女性叶酸缺乏的营养干预

The Nutrition Intervention of the Lack of Folic Acid in Progestational and Pregnant Women

目的研究昆明地区围孕期女性血清叶酸水平及叶酸缺乏的患病率,并对叶酸缺乏者进行饮食指导/叶酸补充的干预.方法入选对象进行血清叶酸检测,检测异常的女性进行营养分析指导/叶酸补充(0.4 mg/d)干预,4周后再次测量其血清叶酸水平.结果昆明地区围孕期女性平均血清叶酸水平为26.86 nmol/L,叶酸缺乏的患病率为18.01%;没有发现血清叶酸水平超过正常参考值者;对于围孕期叶酸缺乏的女性给予个体化的营养指导/叶酸补充,4周后复查血清叶酸,营养干预组有97.88%达到正常值,服药组99.4%达到正常值.结论围孕期补充叶酸是预防新生儿神经管畸形的有效方法,但是其安全性一直有争议,对于围孕期血清叶酸缺乏的女性可以通过营养膳食干预达到正常的血清叶酸水平,而且通过个体化的营养指导进行干预可避免药物的一些副作用,更加安全有效.

Objective To study the level of folic acid and the rate of the lack of folic acid in progestational and pregnant women in Kunming area, and intervene them by diet or folic acid.Methods All of the women＇s level of folic acid were dectected,and these women with abnormal level were intervened by nutrition supply or folic acid supply（0.4 mg/day）.After 4 weeks the level of folic acid was dectected again.Results（1） The average folic acid level of progestational and pregnant women in Kunming area was 26.86%,and the rate of folic acid lack was 18.01%;（2） Nobody＇s level of folic acid was up the normal reference value;（3） By nutrition supply or folic acid supply,detecting the level of folic acid again after 4 weeks,97.88% of progestational and pregnant women were among the normal range for the nutrition supply,and 99.4% of progestational and pregnant women were among the normal range for the folic acid supply.Conclusions It is an effective method to prevent neuraltube defects about neonatus by folic acid supply,but the safe of which is disputed about progestational and pregnant women with lack of folic acid.It＇s more safe and effective to supply nutrition intervention so as to avoid some sideeffects of drug.