摘要
建立一种准确定性奶茶等样品中亚甲基双氧甲基卡西酮(bk-MDMA)的电喷雾串联质谱检测方法。样品通过甲醇提取,提取液高速离心后用滤膜过滤,上机液用蠕动泵进样进行电喷雾串联质谱定性分析。通过母离子扫描和子离子扫描研究了bk-MDMA的质谱裂解途径,通过分析比较选择合适的定性离子。通过对锥孔电压、碰撞电压等质谱条件的优化和基质干扰分析,建立了合适的串联质谱检测条件。电喷雾串联质谱方法与GC-MS方法相比更加快速简便,通过串联质谱的二级质谱定性准确度更高。利用本方法对5个物证实际样品进行了分析,结果显示均含有bk-MDMA。本方法快速、准确、灵敏度高,可广泛用于司法物证鉴定等领域bk-MDMA的定性分析。
A method for analysis of 3,4-methylenedioxy-N-methylcathinone （bk-MDMA） in milk tea powder samples was established by using electrospray ionization tandem mass spectrometry （ESI-MS/MS）. The sample was extracted with methanol, then high-speed centrifuged. The supematant was filtered and injected into ESI tandem mass by peristaltic pump. Proper qualitative ions of bk-MDMA were selected in mass scan and daughter scan mode. Tandem mass parameters such as cone voltage and collision energy were optimized, and the matrix interference was also investigated. Compared with GC-MS method, this method is faster, more convenient and sensitive, bk-MDMA was detected in five real samples analyzed with the established method. This method is rapid, accurate, sensitive and suitable for the qualitative analysis of bk-MDMA in criminal investigation and judicial identification.
出处
《刑事技术》
2015年第6期510-512,共3页
Forensic Science and Technology
