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聚乙二醇-400中CuSO_4/KI催化的串联反应合成2-苯基咪唑并[1,2-a]吡啶

Synthesis of 2-phenyl-imidazo[1,2-a]pyridines via CuSO_4/KI catalyzed cascade reaciton of o-amino pyridine with acetophenone in PEG-400
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摘要 以聚乙二醇400(PEG-400)作溶剂,通过CuSO4/KI催化的邻氨基吡啶与苯乙酮的串联式缩合-环化-芳构化反应,发展出一种高效且环境友好型的合成2-苯基咪唑并[1,2-a]吡啶的方法.该方法具有操作简单、使用无毒性PEG-400作反应介质、催化剂安全价廉等优点.所有产物结构经1 H NMR及13 C NMR进行了确认. An environmentally friendly method has been developed for efficient synthesis of 2-phenyl-imi-dazo [1,2-a]pyridines via CuSO 4/KI catalyzed condensation-cyclization-aromatixation cascade reation of o-aminopyridine with acetophenone in polythylene glycol 400 （PEG-400）.This method exhibited the ad-vatages of simple operation,use of nontoxic PEG-400 as the reaction medium,employing safe and cheap catalyst.The structures of all products were confimed by 1 H NMR and 1 3 C NMR.
作者 王方建 梁瑞瑞 周良 谭亚军 张泽
机构地区 安徽工程大学生物与化学工程学院
出处 《安徽工程大学学报》 CAS 2015年第5期36-40,共5页 Journal of Anhui Polytechnic University
基金 国家自然科学基金资助项目(21242013) 国家级大学生创新创业训练计划基金资助项目(201410363021)
关键词 聚乙二醇 硫酸铜 碘化钾 咪唑并1 2-a吡啶 polyethylene glycol copper sulfate potassium iodide imidazo [1,2-a]pyridine
分类号 O625.4 [理学—有机化学]
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参考文献14

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安徽工程大学学报
2015年 第5期

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