姜黄素衍生物的合成及其抗肿瘤活性

Synthesis and Anti-tumor Activity of Curcumin Derivatives

以姜黄素、2-氯甲基吡啶和2-氯-5-氯甲基吡啶等为原料,制备了三种新型含氮杂环类姜黄素衍生物A、B和C,经核磁,质谱确定了这些目标化学物的结构,并使用MTT法对其抗肿瘤活性进行了测试。结果表明三种目标化合物均具有比5-氟尿嘧啶(5-Fu)更强的抗肿瘤活性。

Three kinds of novel curcumin derivaties containing azaheterocyclic were prepared using curcmin, 2-chloromethyl pyridine and 2-chloro-5-chloromethyl pyridine as starting material, the structure of the target compounds were confirmed by 1H-NMR, Mass Spectra. The anti-tumor activity of the target compounds were measured by the MTT assay, the results show that there compounds possess stronger anti-tumor activity against tested tumor cell lines than that of curcumin.