丙泊酚治疗癫痫持续状态疗效观察

Curative Effect Observation of Propofol in the Treatment of Status Epilepticus

目的:观察丙泊酚治疗癫痫持续状态的临床效果。方法:选取2012年1月-2014年12月笔者所在医院收治的癫痫持续状态患者42例,分为丙泊酚组与咪达唑仑组,每组21例。记录比较两组患者癫痫发作控制成功率、发作控制时间、气管插管率、低血压发生率及死亡率。结果:两组患者的癫痫发作控制成功率、低血压发生率及死亡率比较,差异均无统计学意义(P>0.05);丙泊酚组的平均控制时间短于咪达唑仑组,气管插管率低于咪达唑仑组,差异均有统计学意义(P<0.05)。结论:丙泊酚治疗癫痫持续状态效果显著,疗效迅速、气管插管率低,值得临床推广使用。

Objective：To observe the clinical effect of Propofol in the treatment of status epilepticus.Method：42 cases with status epilepticus in our hospital from January 2012 to December 2014 were selected, they were divided into Propofol group and Midazolam group,21 cases in each group.The success rate of seizure control,seizure control time, the rate of endotracheal intubation, the incidence of hypotension and the mortality rate of two groups were recorded and compared.Result：The success rate of seizure control, the incidence of hypotension and the mortality rate were no significant differences between two groups（P〉0.05）,but the seizure control time in Propofol group was shorter than that in Midazolam group,and the rate of endotracheal intubation was lower than that in Midazolam group,the differences were statistically significant（P〈0.05）.Conclusion：Propofol in the treatment of status epilepticus has a remarkable efficacy,which has rapid efficacy and low rate of endotracheal intubation.It is worthy of clinical application.