线粒体调控心律失常发生的研究进展

Mitochondrial mechanisms underlying cardiac arrhythmias

线粒体是维持细胞功能稳态的重要的细胞器。在心肌细胞中,线粒体占据了心肌细胞体积的30%,其在协调心脏高能耗及心脏电-机械功能中起着至关重要的作用。线粒体的结构与功能缺陷与病理性心肌肥大及心力衰竭的发生有着密切联系。近年来,线粒体的能量代谢震荡、线粒体膜离子通道异常以及线粒体与其他亚细胞器之间的交流异常在心律失常发生中的作用日益受到关注。现就心律失常发生的线粒体相关机制作一综述。

Mitochondria are the pivotal organelles for cellular fate and biological functions. In the cardiomyocytes, mitochondria occupy 30% of the cellular volume, and critically coordinate the high demand of energy with electric- mechanical function. Structural and functional remodeling of mitochondria has been reported to promote the development of pathological cardiac hypertrophy and heart failure. Emerging evidences have shown that mitochondrial metabolic oscillation, disorders in mitochondrial membrane ion channels and the disrupted communication between mitochondria and other organelles are intimately involved in the cardiac arrhythmogenesis. In the short review, we summarize the recent progresses in the mitochondrial mechanisms underlying cardiac arrhythmias