健脑补肾丸联合银杏叶片治疗轻度认知功能障碍

Jiannao Bushen Pills Combined with Ginkgo Leaves Tablet in Treatment with Mild Cognitive Impairment

目的:观察健脑补肾丸联合银杏叶片治疗轻度认知功能障碍(MCI)的临床疗效及对氧化应激和乙酰胆碱脂酶(Ach E)的影响。方法:将60例MCI患者随机按数字表法分为对照组和治疗组各30例,另选30名志愿者作为正常组;对照组给予盐酸多奈哌齐片,2.5 mg·d-1,餐后服;治疗组采用健脑补肾丸,15粒/次,2次/d,银杏叶片,2片/次,3次/d;两组疗程均为3个月。观察治疗前后两组临床记忆量表各项指标评分及记忆商(MQ)变化,并根据MQ增殖评估临床疗效;检测治疗前后血清中丙二醛(MDA),超氧化物歧化酶(SOD)和乙酰胆碱脂酶(ACh E)水平。结果:MCI患者的临床记忆量表各项指标评分及MQ比正常组(志愿者)明显下降(P<0.01);治疗后对照组的优良率为46.67%,治疗组为76.67%,治疗组优于对照组(P<0.05);治疗后两组除联系记忆外其他临床量表各项指标及MQ均显著升高(P<0.05,P<0.01);治疗后治疗组在指向记忆、图像自由回忆、人像特点回忆及记忆商评分均优于对照组(P<0.05);两组治疗后血清MDA,ACh E水平均较治疗前降低,SOD较治疗前升高(P<0.05,P<0.01);治疗后治疗组血清MDA,ACh E水平低于对照组,SOD水平高于对照组(P<0.05);治疗组治疗后MDA,ACh E和SOD水平与正常组比较差异均无统计学意义。结论:健脑补肾丸联合银杏叶片能有效改善MCI患者的记忆功能,其作用机制可能与减轻氧自由基损伤,降低ACh E活性有关。

Objective： To observe the clinical efficacy of Jiannao Bushen pills combined with Ginkgo Leaves tablet（ GLT） in treating mild cognitive impairment（ MCI） and its influence on oxidative stress and acetylcholinesterase（ ACh E）. Method： Sixty cases MCI patients were randomly divided into the control group and treatment group according to the method of random digits table,30 patients for each group. Besides,another 30 healthy volunteers were selected as the normal group. The control group received Donepezil hydrochloride tablets,2. 5 mg ·d^- 1 after meals. The treatment group received Jiannao Bushen pills（ 15 pieces / time,2 times / d）combined with GLT（ 2 tablets / time,3 times / d）,with the treatment course of 3 months for both groups. Changes of scores of all indexes of clinical memory scale and memory quotient（ MQ） before and after treatment were observed for both groups,and clinical therapeutic effect was evaluated by using MQ increasing values. Change of malondialdehyde（ MDA）,superoxide dismutase（ SOD）,and ACh E levels before and after treatment were observed. Result： All indexes of clinical memory scale and MQ in MIC patients were significantly lower than those in normal group（ volunteers）（ P 〈0. 01）. After treatment,the satisfaction rate was 46. 67% in the control group and 76. 67% in the treatment group,with significant difference between the two groups（ P〈 0. 05）. After treatment,the scores of all indexes of clinical memory scale of two groups except associated memory were significantly increased（ P 〈0. 05,P 〈0. 01） in both groups,while the scores in direction memory,picture free memory,associated memory of human picture characteristics,and MQ in the treatment group were higher than those in the control group（ P 〈0. 05）. Serum MDA and ACh E levels were decreased and SOD was increased in both groups after treatment（ P 〈0. 05,P 〈0. 01）. Serum MDA and ACh E levels in the treatment group were lower than those in control group after treatment,while SOD level in the treatment group was higher than that in the control group after treatment（ P 〈0. 05）. After treatment,there was no statistical difference in MDA,ACh E,and SOD levels between treatment group and normal group. Conclusion： Jiannao Bushen pils combined with GLT can effectively improve the memorial function of MCI patients,and its therapeutic mechanism may be associated with alleviating the damage of oxygen free radicals and depressing the activity of ACh E.