《中医方剂大辞典》中治疗呕吐方剂的用药规律分析

Composition Principles of Prescriptions for Emesis in Prescription of Traditional Chinese Medicine Dictionary

目的:分析《中医方剂大辞典》中治疗呕吐方剂的组方规律。方法:采用中医传承辅助平台(2.5),提取《中医方剂大辞典》中治疗呕吐的方剂,录入方剂信息,构建数据库,使用软件的关联规则、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法,分析治疗呕吐方剂中常用的药物、组合规律、核心组合及新方。结果:通过对《中医方剂大辞典》中305首止吐方剂的分析,共涉及中药174味,出现频次≥10的药物49味,总结了常用药对及药物组合45个、潜在核心组合58个,并演化新处方9个。结论:明确了《中医方剂大辞典》中治疗呕吐方剂的用药规律,常用药物以健脾助运的陈皮、化痰降逆止呕的半夏、温中止呕的生姜为主,并可适当配伍补益药物。本研究为中医止呕临床用药和中药新药研发提供了参考依据。

Objective： To analyze the composition principles of prescriptions for emesis in Prescription of Traditional Chinese Medicine Dictionary. Method： The prescriptions for emesis in Prescription of Traditional Chinese Medicine Dictionary were selected,and traditional Chinese medicine inheritance support system（ TCMISS）V2. 5 was used to enter information and build the database. The commonly used herbs,combination principles,core combinations and new combinations in the prescriptions for emesis were analyzed with data mining methods,such as association rules, improved mutual information method, complex system entropy clustering and unsupervised hierarchical clustering. Result： Total 174 herbs were involved in the 305 prescriptions for emesis,including,49 herbs with the frequency of more than 10 times, forty-five commonly used herb pairs and combinations,fifty-eight potential core combinations and nine newly developed prescriptions. Conclusion： The composition principles of prescriptions for emesis in Prescription of Traditional Chinese Medicine Dictionary are defined,which provides references for clinical medication and new drug development. The commonly used herbs are mainly citrus,pinellia,ginger and some tonics.