清胰汤治疗重症急性胰腺炎的临床疗效的Meta分析

Meta-analysis of Effectiveness of Qingyi Decoction in Treatment of Severe Acute Pancreatitis

目的:系统评价清胰汤辅助治疗重症急性胰腺炎的临床疗效。方法:采用Meta分析方法,制定原始文献的纳入标准、排除标准及检索策略,计算机检索中国知网(1979—2014年),万方数据知识服务平台(1990—2014年),中国生物医学文献数据库(1978—2014),pubmed(1966—2014)等中英文数据库,按照Cochrane评价标准评价文献质量。结果:共纳入19项研究。清胰汤辅助治疗组首次排便时间[WMD=-2.098,95%CI(-2.739,-1.456),P<0.01)],腹痛缓解时间[WMD=-3.008,95%CI(-3.689,-2.326),P<0.01],住院时间[WMD=-7.633,95%CI(-8.449,-6.756),P<0.01],病死率[OR=2.719,95%CI(1.717,4.306),P<0.01]均优于对照组,有统计学意义。结论:清胰汤辅助治疗重症急性胰腺炎可显著降低患者病死率,并可缩短患者首次排便时间、腹痛缓解时间及住院时间。

Objective： To evaluate the effectiveness of Qingyi decoction in the treatment of severe acute panereatitis in a systematic review. Method： The inclusion and exclusion criteria and retrieval strategies were made using Meta-analysis methods,with computer retrieval of CNKI（ 1979—2014）,Wanfang Data Knowledge Service Platform（ 1990—2014）,Chinese Biomedical Database（ 1978—2014）,pubmed（ 1966—2014） and other Chinese and English databases. The quality of the literatures was assessed according to Cochrane review criteria.Result： The 19 studies were included. Compared with control group,the adjunctive therapy with Qingyi decoction group had significant differences in the time of first defecation [WMD =- 2. 098,95% CI（- 2. 739,- 1. 456）,P 〈0. 01） ],the time of stomach ache relief [WMD =- 3. 008,95% CI（- 3. 689,- 2. 326）,P〈 0. 01 ],hospital stay（ days） [WMD =- 7. 633,95% CI（- 8. 449,- 6. 756）,P 〈0. 01 ],case fatality rate [OR =2. 719,95% CI（ 1. 717,4. 306）,P 〈0. 01]. Conclusion： The adjunctive therapy with Qingyi decoction in severe acute pancreatitis can significantly decrease the case fatality rate,shorten the first time of defecation,stomachache relief time and hospital stay.