小卒中/TIA双联抗血小板治疗后血浆CRP水平的变化

Changes of CRP levels in plasma with minor stroke/TIA after treatment with dual antiplatelet

目的探讨小卒中/短暂性脑缺血发作(transient ischemic attack,TIA)患者双联抗血小板治疗后血浆C反应蛋白(C-reactive protein,CRP)的变化。方法前瞻性纳入发病24 h内的小卒中/TIA患者130例。对照组:70例,入院后给予阿司匹林每日100 mg治疗,并给予他汀等常规治疗。实验组60例,入院后给予阿司匹林每日100 mg联合氢氯吡格雷75 mg治疗,并给予他汀等常规治疗。所有患者均于入院次日清晨空腹抽血测定CRP,并于治疗后1 w再行血浆CRP检测。结果阿司匹林联合氢氯吡格雷治疗1 w后血浆CRP明显降低(4.32 mg/L VS 2.21 mg/L,P<0.01)。阿司匹林组治疗前后无明显变化(3.74 mg/L VS 3.26 mg/L)。结论阿司匹林联合氢率吡格雷可显著降低小卒中/TIA血浆CRP水平。

Objective To investigate the change of C-reactive protein（ CRP） in plasma after treatment with dual antiplatelet in patients of minor stroke / TIA. Methods 130 patients with minor stroke / TIA within 24 hours were collected. In control group,70 patients were given aspirin 100 mg daily,meantime given statins and other conventional treatment.In experimental group,60 patients were given aspirin 100 mg and clopidogrel 75 mg daily. And the other treatments were same between the two groups. The level of CRP in fasting blood was measured when all patients were admitted to hospital in the next morning. The level of CRP was measured again after one week. Result The level of CRP was significantly lower in experimental group after one week than that of control group（ 4. 32 mg / L VS 2. 21 mg / L,P〈0. 01）. Control group had no significant changes（ 3. 74 mg / L VS 3. 26 mg / L）. Conclusions Aspirin combined clopidogrel can significantly reduce the level of CRP in plasma of minor stroke / TIA.