缺血性脑卒中患者血清中同型半胱氨酸化蛋白质抗体及危险因素分析

Analysed the levels of antibodies against N-homocysteinylated proteins and the risk factors in serum of ischemic stroke patients

目的探讨缺血性脑卒中患者血清中同型半胱氨酸化蛋白质抗体水平,比较与脑卒中发病危险因素。方法留取缺血性脑卒中患者(n=75)与正常体检人员(n=36)的血清,ELISA法分析血清中同型半胱氨酸化蛋白质抗体的水平,并分析血清中同型半胱氨酸、生化指标、叶酸和维生素B_(12)水平。结果脑卒中组患者血清中同型半胱氨酸水平明显升高,与正常对照组比较,差异有统计学差异(P<0.01)。脑卒中组患者血清中同型半胱氨酸化蛋白质抗体水平明显升高,与正常对照组比较,差异具有统计学意义(P<0.01)。脑卒中组患者血清中甘油三酯、低密度脂蛋白、血糖和维生素B_(12)呈升高趋势,血糖值与正常对照组比较,差异有统计学差异(P<0.05);脑卒中患者血清中总胆固醇、高密度脂蛋白和叶酸水平下降。结论缺血性脑卒中患者血清中同型半胱氨酸化蛋白质抗体水平与缺血性脑卒中的发病有一定的关系,多因素促使了该病的发生。

Objective To explore the levels of antibodies against homocysteinylated proteins in ischemic stroke patients,to compare the related factors. Methods We collected the serum of ischemic stroke patients（ n = 75） and medical patients（ n = 36）,ELISA assay detected the levels of antibodies against homocysteinylated proteins,and then analyzsed levels of homocysteine,biochemical indicators,folic acid and vitamin B12. Results The levels of Hcy in ischemic stroke patients group was significantly higher than that in the control group,which showed a statistical difference（ P〈0. 01）. Triglyceride,Low density lipoprotein,Blood sugar and Vitamin B12 in stroke patients group showed an increasing trend,but there was also a statistical significance in Blood sugar（ P〈0. 05）. The Total Cholesterol,High density lipoprotein and folic acid in the ischemic stroke patients group were lower than control group. Conclusion The levels of antibodies against homocysteinylated proteins may affect the incidence of ischemic stroke,and it is a mutifactor discrease.