一种流化床喷雾制粒技术在头孢克洛颗粒制备中的应用

The fluidized bed atomization granulation in application of preparation of Cefaclor granules

目的:研究流化床制粒设备在头孢克洛颗粒制备中的应用。方法:采用正交试验法,选定进风温度、喷入粘合剂浓度、喷浆速度、进风量为考察因素,每个因素取3个水平,筛选头孢克洛颗粒流化床制粒的最佳工艺。结果:最佳工艺条件为粘合剂为10%PVPK30、进风温度70℃、喷入速度50m L·min-1,进风量为1400m3·h-1。结论:本方法生产工艺简单,自动化程度更高,是药物制剂现代化生产的一条良好途径。

Objectives：To study the fluidized bed atomization granulation in application of preparation of Cefaclor granules. Methods： Select generation temperature,the spray adhesive concentration,the gunite speed,wind capacity to advance to optimize the technical process of Cefaclor granules by fluidized bed atomization granulation with orthogonal design. Results：The optimized conditions were as follows：the spray adhesive concentration was 10%PVPK30,the generation temperature was 70℃,the gunite rate was 50mL/min,the wind capacity to advance was 1400m3·h^-1 Conclusion：The method is simple and automaticity is higher. It is a good pathway for Cefaclor granules up to date preparation. Key Words：