氟伐他汀治疗老年心力衰竭临床疗效观察及对相关指标影响研究

Fluorine cut statin treatment of senile heart failure clinical curative effect of observation and research influence on relevant indicators

目的:探讨氟伐他汀治疗老年心力衰竭的临床疗效及对心功能、血浆N-末端脑钠肽、炎性因子水平的影响。方法:以50例老年心力衰竭患者作为研究对象,随机分为两组,每组25例。对照组给予临床常规治疗,观察组在对照组的基础上给予氟伐他汀治疗,对比分析两组治疗效果及治疗前后心功能指标、血浆N-末端脑钠肽、炎性因子水平的变化情况。结果:观察组治疗总有效率为88.0%,明显高于对照组的72.0%(P<0.05)。两组患者治疗前NT-Pro BNP、hs-CRP、TNF-a、IL-6水平以及LVIDd、LVEF比较,差异无统计学意义(P>0.05);治疗后,观察组NT-Pro BNP、hs-CRP、TNF-a、IL-6水平、LVIDd、LVEF均优于对照组,差异显著(P<0.05)。结论:氟伐他汀治疗老年心力衰竭的临床效果显著,可有效改善患者心功能和血管内皮功能障碍,减少炎性因子的刺激作用,对改善患者预后,提高生活质量具有重要意义。

Purpose：Explore fluorine laval statin treatment the curative effect of senile heart failure and cardiac function, plasma N - terminal brain natriuretic peptide, the influence of inflammatory factor levels.Methods：In 50 cases of senile heart failure patients as the research object, randomly divided into two groups, each group of 25 cases. Control group for clinical routine treatment, the observation group in the control group on the basis of fluconazole lava] statin therapy, compared two groups of patients before and after the treatment effect and treatment of cardiac function index, plasma N - terminal brain natriuretic peptide, the change of inflammatory factor levels. Resuhs：Treatment the total effective rate was 88.0%, the observation group was obviously higher than that of control group 72.0%（P〈 0.05）. Two groups of patients before treatment the NT - ProBNP, hs - CRP, TNF - a, IL - 6 levels and LVIDd, LVEF, there was no statistically significant difference （P〉0.05）; After treatment, the observation group of NT - ProBNP, hs CRP, TNF, IL - 6 level, a LVIDd and LVEF were superior to control group, significant difference （P〈O.05）.Conclusion：Fluorine felling of statins in the treatment of senile heart failure effect is remarkable, which can effectively improve cardiac function and vascular endothelial dysfunction in patients with, reduce the stimulation of inflammatory factor, for improving the prognosis of patients, is of great significance to improve the quality of life.