甲巯咪唑治疗甲状腺功能亢进症患者的临床疗效与安全性研究

Research of clinical effect and safety by methimazole in the treatment of hyperthyroidism patients

目的探讨甲巯咪唑治疗甲状腺功能亢进症(甲亢)患者的临床疗效与安全性。方法 143例甲亢患者,随机分为甲巯咪唑组(n=80)和丙硫氧嘧啶组(n=63),分别给予甲巯咪唑和丙硫氧嘧啶治疗。观察并比较两组治疗疗效和不良反应发生情况。结果甲巯咪唑组治疗总有效率为96.25%,丙硫氧嘧啶组为90.48%,组间比较差异无统计学意义(P>0.05);甲巯咪唑组血细胞计数异常,皮疹、皮肤瘙痒发生率明显高于丙硫氧嘧啶组,而肝功能指标异常发生率明显低于丙硫氧嘧啶组,差异均具有统计学意义(P<0.05)。结论甲巯咪唑治疗甲亢的疗效确切,易引起血细胞减少和皮疹,对肝功能影响较少。

Objective To investigate clinical effect and safety by methimazole in the treatment of hyperthyroidism patients. Methods A total of 143 patients with hyperthyroidism were randomly divided into methimazole group （n=80） and propylthiouracil group （n=63）. They respectively received methimazole and propylthiouracil for treatment. Their curative effects and adverse reactions were observed and compared. Results The total effective rate was 96.25% in the methimazole group, and 90.48% in the propylthiouracil group. Their difference had no statistical significance （P〉0.05）. Methimazole group had obviously higher incidences of abnormal blood cell count, rash, and pruritus than propylthiouraeil group, while it had much lower incidence of abnormal liver function index than propylthiouraeil group. Their differences all had statistical significance （P〈0.05）. Conclusion Methimazole contains precise effect in treating hyperthyroidism. It can easily cause hypocytosis and rash, with less influence on liver function.