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氟伐他汀缓释片剂对冠心病介入患者氧化应激反应的影响

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摘要 目的分析与探究氟伐他汀缓释片剂对冠心病介入患者氧化应激反应的影响。方法 60例冠心病介入患者,按随机数表法分为对照组、普通剂组和缓释剂组,各20例。对照组术前给予患者安慰剂,术后给予常规治疗,普通剂组术前及术后给予患者氟伐他汀普通剂,缓释剂组术前术后给予患者氟伐他汀缓释剂,对比三组患者服药前、术前、术后外周血丙二醛(MDA)、活性氧簇(ROS)、一氧化氮(NO)等氧化应激因子水平以及随访数月后患者的生活质量、再入院率不良反应等。结果三组患者外周血中MDA、NO、ROS的水平比较差异有统计学意义(P<0.05);普通剂组患者比对照组患者生活质量评分高,再次住院率及不良心血管事件率低,而缓释剂组生活质量评分较前两组更高,再次住院率及不良心血管事件率较前两组更低,差异有统计学意义(P<0.05)。结论氟伐他汀缓释剂可明显降低冠心病介入患者的氧化应激反应,在临床上值得推广应用。
作者 刘艳
出处 《中国现代药物应用》 2015年第24期91-92,共2页 Chinese Journal of Modern Drug Application
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