摘要
目的:分析血糖控制不佳的2型糖尿病(type 2 diabetes mellitus,T2DM)患者胰岛β细胞分泌功能的特点。方法:430例T2DM患者根据血糖化血红蛋白(Hb A1C)水平分为三组,行胰岛素释放试验,并根据相应公式计算反映胰岛β细胞功能的指标,分析三组差异;结果:随着血Hb A1c水平增高,血糖水平增高,其曲线下面积(area under curve,AUC)增大(P<0.05);C肽和胰岛素水平减低,AUC减少(P<0.05);血糖控制不佳时,HOMAβ、MBCI、IGI30、DI、SUIT 0 min、SUIT 120 min和CPR index减小,除MBCI值在7%<Hb A1c≤10%组和Hb A1c>10%组间差异无统计学意义外,其他的指标在三组间差异均有统计学意义(P<0.05)。结论:血糖控制对于胰岛β细胞分泌功能的保护至关重要。
Objective: To assess the insulin secretion function of pancreas β cells in T2DM patients with poor glucose control. Methods: A total of 430 T2DM patients were randomly divided into 3 groups according to their serum HbAlc level. Insulin releasing test was manipulated and index suggesting insulin secretion function of pancreas cells were calculated. Results: The level of glucose and area under curve (AUC) were increased and those of insulin and c-peptide were decreased as HbAlc was increased. HOMAβ, MBCI, IGI30, DI, SUIT 0 min, SUIT 120 min and CPR index all reduced followed with poor controlled glucose. Conclusion: Suitable glucose management is vital for the protection of insulin secretion function in pancreas βcells for T2DM patients.
出处
《临床与病理杂志》
2015年第11期1974-1978,共5页
Journal of Clinical and Pathological Research