血糖控制不佳的2型糖尿病患者胰岛β细胞分泌功能的特点研究

The investigation of insulin secretion function of pancreas β cells in poor glucose control type 2 diabetic patients

目的:分析血糖控制不佳的2型糖尿病(type 2 diabetes mellitus,T2DM)患者胰岛β细胞分泌功能的特点。方法:430例T2DM患者根据血糖化血红蛋白(Hb A1C)水平分为三组,行胰岛素释放试验,并根据相应公式计算反映胰岛β细胞功能的指标,分析三组差异;结果:随着血Hb A1c水平增高,血糖水平增高,其曲线下面积(area under curve,AUC)增大(P<0.05);C肽和胰岛素水平减低,AUC减少(P<0.05);血糖控制不佳时,HOMAβ、MBCI、IGI30、DI、SUIT 0 min、SUIT 120 min和CPR index减小,除MBCI值在7%<Hb A1c≤10%组和Hb A1c>10%组间差异无统计学意义外,其他的指标在三组间差异均有统计学意义(P<0.05)。结论:血糖控制对于胰岛β细胞分泌功能的保护至关重要。

Objective： To assess the insulin secretion function of pancreas β cells in T2DM patients with poor glucose control. Methods： A total of 430 T2DM patients were randomly divided into 3 groups according to their serum HbAlc level. Insulin releasing test was manipulated and index suggesting insulin secretion function of pancreas cells were calculated. Results： The level of glucose and area under curve （AUC） were increased and those of insulin and c-peptide were decreased as HbAlc was increased. HOMAβ, MBCI, IGI30, DI, SUIT 0 min, SUIT 120 min and CPR index all reduced followed with poor controlled glucose. Conclusion： Suitable glucose management is vital for the protection of insulin secretion function in pancreas βcells for T2DM patients.