足月新生儿高未结合胆红素血症与血清肝功能、心功能、神经功能指标的相关性分析

Correlation analysis of full-term newborns unconjugated hyperbilirubine-mia and serum indicators of liver function, cardiac function, neurological function

目的分析足月新生儿高未结合胆红素血症与血清肝功能、心功能、神经功能指标的相关性。方法选择2014年9月-2015年9月潍坊医学院附属青岛市胶州中心医院（以下简称“我院”）收治的足月新生儿高未结合胆红素血症患儿102例作为观察组．另取同期在我院出生且因咽下综合征或轻度吸入性肺炎在我院住院的血清胆红素水平正常的足月新生儿98例作为对照组。比较两组新生儿的血清肝功能、心功能、神经功能指标值差异。结果观察组患儿的血清总胆红素水平[（254．19±23．81）μmol／L]高于对照组[（113．19±8．67）μmol／L]，差异有统计学意义（P〈0．05）；观察组患儿的血清谷丙转氨酶（ALT）[（56．82±3．27）U／L]、谷草转氨酶（AST）【（89．82±7．34）U／L]、谷酰转肽酶（GGT）[（123．71±19．83）U/L均高于对照组【（32．09±2．61）、（70．53±4．63）、（97．83±8．24）U／L]，差异均有统计学意义（P〈0．05）；观察组患儿的磷酸肌酸激酶同工酶（CK—MB）【（73．82±1．27）U／L】、磷酸肌酸激酶（CK）[（324．17±43．75）U／L]、人S100B蛋白（S-100B）【（1．23±2．18）ng／mL]、脑型同工酶（CK—BB）[（11．21±1．63）mol／L】、血清神经元特异性烯醇化酶（NSE）[（23．31±3．88）μg/L]均高于对照组【（53．29±5．88）U/L、（114．28±15．97）U／L、（0．71±0．09）ng／mL、（5．27±0．76）mol／L、（10．67±1．75）μg／L]，差异均有统计学意义（P〈0．05）；足月新生儿高未结合胆红素血水平与A坍、AST、GGT、CK—MB、CK、S-IOOB、CK—BB、NSE水平呈正相关（P〈0．05）。结论足月新生儿高未结合胆红素血症可能会导致患儿肝功能、心功能及神经功能受损，且胆红素水平与靶器官损伤程度呈正相关。

Objective To analyze the correlation of full-term newboms unconjugated hyperbilirubinemia with serum index of liver function, heart function, nerve function. Methods 102 cases of full-term newborns with unconjugated hyperhilirubinemia from September 2014 to September 2015 in Jiaozhou Central Hospital of Qingdao City Affiliated to Weifang Medical College （＂our hospital＂ for short） were selected as observation group, 98 normal full-term newborns with swallowing syndrome or mild aspiration pneumonia born in our hospital in the same period were selected as control group. Serum levels of liver function, heart function, nerve function in the two groups were compared. Results Serum levels of total bilirubin in the observation group was （254.19±23.81） μmol/L, and the control group was （113.19± 8.67） μmol/L, the difference of two groups was statistically significant （P 〈 0.05）; in the observation group, serum levels of ALT, AST and GGT were （56.82±3.27）, （89.82±7.34）, （123.71±19.83） U/L respectively, were higher than those of the control group [（32.09±2.61）, （70.53±4.63）, （97.83±8.24） U/L], the differences were statistically significant （P 〈 0.05）; in the observation group, serum levels of CK-MB, CK, S-100B, CK-BB, NSE were （73.82±1.27） U/L, （324.17±43.75） U/ L, （1.23± 2.18） ng/mL, （11.21±1.63） mol/L, （23.31±3.88） μg,/L respectively, were higher than those of the control group [（53.29±5.88） U/L, （114.28±15.97） U/L, （0.71±0.09） ng/mL, （5.27±0.76） mol/L, （10.67±1.75） μg/L], the differences were statistically significant （P 〈 0.05）. Bilirubin level of neonatal with unconjugated hyperbilirubinemia was positively associated with levels of ALT, AST, GGT, CK-MB, CK, S-100B, CK-BB, NSE （P 〈 0.05）. Conclusion Unconjugated hyperbilirubinemia of full-term newborns can lead to function damage of liver, cardiac and neurological, there is positive correlation between bilirubin level and damage degree of target organ.