探讨舍曲林合并喹硫平治疗强迫症的疗效及安全性

To Investigate the Efficacy and Safety of Sertraline Combine With Quetiapine in Treatment of Obsessive Compulsive Disorder

目的 探讨舍曲林合并喹硫平治疗强迫症的临床效果及安全性.方法 选取2014年1月～2015年1月我院神经科收治的强迫症患者100例,将患者随机分为观察组与对照组,每组50例.对照组给予舍曲林进行治疗,观察组在此基础上联合喹硫平进行治疗,对比两组患者的治疗效果及不良反应发生情况.结果 观察组的治疗总有效率为94%,高于对照组78%,P＜0.05,差异具有统计学意义.两组患者在不良反应症状量表评分上比较,P＞0.05,差异不具有统计学意义.结论 舍曲林合并喹硫平治疗强迫症临床效果显著,不良反应发生率较低.

Objective To investigate the efficacy and safety of sertraline combine with quetiapine in treatment of obsessive-compulsive disorder. Methods Selected 100 patients with obsessive-compulsive disorder neurology from January 2014 to January 2015 in our hospital, were randomly divided into the observation groups and the control group, each group had 50 cases. The control group treated with sertraline, the observation group were based on this joint quetiapine treatment, compared two groups of patients with the therapeutic effect and adverse events. Results The observation group total effective treatment of patients was 94%, higher than the control group 78%,P〈0.05, was difference had statistically significance. Compared the symptom scale scores on adverse reactions of two groups,P〉0.05, was no difference had statistically significance.Conclusion Sertraline merger quetiapine OCD significant clinical effect, lower incidence of adverse reactions.