摘要
目的了解头孢哌酮钠/舒巴坦钠对凝血产生不良反应的浓度及在不同浓度梯度凝血项目随时间的变化情况。方法收集本院健康体检者标本100份制成混合血浆,在混合血浆中加入不同浓度抗生素,用ACL-TOP 700测定PT、APTT、TT、FIB及不同时间点凝血项目的结果。结果头孢哌酮钠/舒巴坦钠对PT、APTT、TT的影响与其浓度密切相关,且高浓度其抗生素对凝血因子有抑制作用。结论头孢哌酮钠/舒巴坦钠对凝血功能有影响,使用此抗生素时,应注意监测患者的凝血功能。
Objective To study the concentration of cefoperazone/sulbactam on adverse effects of coagulation and the relation between coagulation factors and time.Methods 100 hybrid plasma from healthy people in our hospital were put in different concentration. PT, APTT, TT, FIB and coagulation factors on different time were detected by ACL-TOP 700. Results PT, APTT, TT were effect by the concentration of cefoperazone/sulbactam. High concentration, the antibiotic could inhibit coagulation factors.Conclusion Cefoperazone/sulbactam could affect coagulation function. The coagulation should be monitored when used these antibiotics.
出处
《中国继续医学教育》
2015年第31期162-163,共2页
China Continuing Medical Education
