孕妇血清总胆汁酸测定的临床意义

Clinical Significance of Serum Total Bile Acid Assay in Pregnant Women

目的探讨孕妇血清总胆汁酸(TBA)水平变化规律。方法检测分析322例不同孕期的孕妇血清TBA水平,134例非孕女性作为正常对照组。结果妊娠早期和中期孕妇血清TBA,与正常对照组比较,差异无统计学意义(P>0.05);妊娠晚期孕妇血清TBA,与正常对照组比较,差异有统计学意义(P<0.01);妊娠期肝内胆汁瘀积症(ICP)及中高度妊娠高血压综合症的孕妇,血清TBA增高。结论孕妇血清TBA随妊娠期延长而升高,它是ICP及妊高症肝损害早期诊断的一个敏感指标,临床医生应把孕妇血清TBA测定做为一个重要常规体检项目。

Objective To investigate the changes of serum total bile acid（TBA）in pregnant women. Methods Serum TBA levels were detected in 322 patients,and 134 non pregnant women as normal control group. Results Serum TBA in early and middle pregnancy,compared with normal control group,the difference was not statistically significant（P〉0.05）,serum TBA in late pregnant women,compared with the normal control group,the difference was statistically significant（P〈0.01）,TBA was significantly higher in the pregnant women with intrahepatic cholestasis of pregnancy（ICP）and the high degree of pregnancy induced hypertension syndrome. Conclusion The serum TBA of pregnant women increased with the prolongation of pregnancy. It was a sensitive index for early diagnosis of ICP and the liver damage of patients with hypertension.