神经肽K物质、P物质对小鼠脾脏和胸腺淋巴细胞的影响

The effects of substance K and substance P on lymphocytes of spleen and thymus in mice

研究了速激肽SK和SP对小鼠脾脏和胸腺淋巴细胞的作用,观察到SK与SP在亚适量的ConA或LPS共同作用下,能促进脾脏细胞的体外增殖和抗体生成。此外,5×10^(-7)M的SK对ConA激活的胸腺细胞有促增殖作用,而SP没有这个效应。FACS分析的结果表明,SK能促使ConA激活的脾脏和胸腺T淋巴细胞亚群发生变化,使脾脏细胞中lyt2^+细胞所占比例上升,而L_3T_4^+细胞比例不变;使胸腺细胞lyt 2^+和L_4^+比例都下降。以上结果表明神经肽SK、SP对免疫反应有调节作用。

effects of tachykinin SK, SP on mouse splenocyte and thymocyte have been studied.It was found that SK and SP can stimulate ConA or LPS-induced splenocyte prolifertion and antibody production (in cluding IgG, IgM, IgA).5 ×10^(-7)M/L SK can stimulate ConA-induced thymocyte proliferation but SP can't. The subsets of T lymphocytes in spleen and thymus have been changed after SK treatment by FACS analysis. These results show that SK and SP may play a significant regulatory role in immune response.