抗体药物在抗感染领域的应用

Application of antibody drugs in the field of anti-infection

近年来,抗体药物蓬勃发展,其治疗领域也从传统的癌症、自身免疫性疾病,逐步扩展到代谢性疾病以及抗感染等领域。相对而言,抗感染领域的抗体药物发展缓慢,目前仅有两个品种上市。病毒、细菌等病原体感染机体的机制复杂,而单克隆抗体仅识别单一抗原表位,这些因素极大地限制了抗体药物的抗感染效果。重组多克隆抗体等新型抗体研发及应用技术的发展,将进一步推动抗感染抗体药物的快速发展。本文重点综述了当前抗体药物在抗感染领域的应用及其发展趋势。

In recent years, with the rapid development of antibody drugs, the antibody-based therapies have gradually expanded from the cancer and autoimmune diseases to metabolic and infectious diseases and so on. However, the development of antibody-based anti-infective drugs is much slower as there are only two kinds of drugs in the market. This is due to the complex infective mechanism of viruses, bacteria and other pathogens, and the monovalent character of monoclonal antibodies that greatly limit the anti-infection effect of antibody drugs. The development and application of novel technologies, such as recombinant polyclonal antibody technology, will greatly accelerate the development of antibody-based anti-infection drugs. This article will introduce the application and trends in the development of antibody-based drugs in the field of anti-infection therapy.