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重组鸡白细胞介素6对重组禽流感病毒H5亚型二价灭活疫苗(H5N1,Re-6株+Re-7株)免疫增强作用的观察 被引量:2

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摘要 为评价重组鸡白细胞介素6(rChIL-6)在商品鸡体内对重组禽流感病毒H5亚型二价灭活疫苗(H5N1,Re-6株+Re-7株)免疫增强作用,将rChIL-6与重组禽流感病毒H5亚型二价灭活疫苗(H5N1,Re-6株+Re-7株)采用肌肉注射方式免疫57日龄麻鸡,分别在疫苗接种前和接种后第7、14、21、35、42天,检测H5N1亚型禽流感病毒(Re-6、Re-7)血凝抑制(HI)抗体水平。结果表明:与灭活疫苗同时注射rChIL-6组比单一注射疫苗组的H5N1 Re-6抗体滴度可提高1.6 log2,Re-7抗体滴度可提高1.8 log2。提示rChIL-6对重组禽流感病毒H5亚型二价灭活疫苗(H5N1,Re-6株+Re-7株)有显著的免疫增强作用。
出处 《中国家禽》 北大核心 2015年第22期49-51,共3页 China Poultry
基金 河南省科技创新人才计划资助项目(豫科人组[2011]1号)
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