食管炎患者真菌感染的特点与药敏分析

Drug sensitivity analysis and characteristics of pathogenic bacteria in patients with esophagitis complicated with fungal infections

目的探讨食管炎患者真菌感染的病原菌特点以及药敏学分析,为临床治疗提供参考依据。方法将2014年3月-2015年2月确诊为食管炎合并真菌感染的59例患者作为研究组,同期选取65例患者作为对照组,对两组患者的临床资料进行对比分析,并对研究组患者进行真菌检测和药敏分析,数据采用SPSS 19.0软件进行统计分析。结果研究组患者在患有糖尿病、应用广谱抗菌药物及强酸抑制药明显多于对照组,差异有统计学意义(P<0.05);研究组患者共分离出59株真菌,以白色假丝酵母菌、热带假丝酵母菌和克柔假丝酵母菌为主,分别占5.59%,28.81%和20.34%;对制霉菌素和两性霉素B的药物敏感性较好,其敏感率均为100.00%。结论对食管炎患者真菌感染进行真菌检测和药敏分析,以保证临床用药的规范性和合理性,有效降低了真菌继发性感染的发生,对真菌性食管炎的预防治疗工作起到积极作用。

OBJECTIVE To research the drug sensitivity and characteristics of pathogenic bacteria in patients with esophagitis complicated with fungal infections, so as to provide the basis for clinical treatment. METHODS From Mar. 2014 to Feb. 2015, 59 cases were selected as the research group who diagnosed as esophagitis with fungal infections. At the same time, 65 patients were selected as the control group. The control group was excluded from the fungal esophagitis. The clinical data of the two groups were compared and analyzed. Fungus detection and drug susceptibility analysis were conducted to the research group. RESULTS In the proportion of patients with dia- betes, broad-spectrum antibiotics, acid inhibitors, the study group was significantly more than the control group （P〈0.05）. From the study group of patients, 59 fungal isolates were isolated from all, there were 6 kinds of fun- gi, and there were mainly Candida albicans, Candida Candida and Candida krusei, accounting for 35. 59%, 28.81% and 20. 34% respectively. The fungi were sensitive to nystatin and amphotericin B and the sensitivity rates were 100%. CONCLUSION Fungus detection and drug susceptibility analysis need to be conducted for pa- tients with esophagifis complicated with fungal infections so that clinical medication and the rationality of drug use can be guaranteed. It can effectively reduce the secondary infections, and have a positive effect on the prevention and treatment of the fungus esophagltis.