血液透析治疗对尿毒症患者BNP水平的影响

Effect of Hemodialysis on the Level of BNP in Patients with Uremia

目的观察尿毒症患者在进行血液透析治疗前后BNP水平的变化,探究血液透析治疗对尿毒症患者BNP水平的影响.方法选取2013年2月到2014年12月在昆明医科大学第一附属医院进行治疗的尿毒症患者共50例,将患者按照入院编号随机分成2组,观察组和对照组患者各25例,对观察组患者入院后给予血液透析治疗;对对照组患者给予一般的治疗,观察2组患者的BNP水平,比较2组患者的治疗效果.结果治疗前两组BUN、Cr、Alb、β2-MG及Hb比较无统计学差异(P>0.05).治疗后2组BUN、Cr均保持稳定,治疗6个月后观察组Alb、β2-MG及Hb明显改善,与治疗前相比有统计学差异(P<0.05),治疗3个月、6个月观察组Alb、β2-MG及Hb明显优于对照组(P<0.05).观察组患者在接受血液透析治疗后BNP水平的变化,观察组患者的BNP水平比对照组患者的BNP水平由明显的变化,组间治疗效果比较具有明显差异(P<0.05).结论临床上对尿毒症患者进行治疗时可以采用血液透析治疗,能有效改善患者的治疗效果,获得较为理想的治疗效果,值得在临床上大力推广.

Objective To observe the change of BNP level in patients with uremia before and after hemodialysis, and to explore the effect of hemodialysis on the level of BNP in patients with uremia. Methods A total of 50 patients for treatment of uremic in our hospital from February 2013 to December 2014 were chosen. The patients were randomly and equally divided into observation group and control group according to the admission number. The patients in the observation group were given blood dialysis treatment, while the patients in the control group received general treatment. The BNP levels of two groups were determined, and the therapeutic effect of the two groups was compared. Results There were no differences in BUN, 2-MG, Alb, beta Cr and Hb between the two groups before treatment （P 〉 0.05） . After treatment, bun and Cr in the two groups remained stable. ALB, beta 2-MG, and Hb of the observation group were significantly improved after 6 months of treatment, which had significant differences compared with those of prior treatment （P 〈 0.05） . After 3 and 6 months of treatment, ALB and beta 2-MG and Hb of observation group were obviously superior to the control group （P 〈 0.05） . The level of BNP after hemodialysis treatment and the effect of treatment were significantly different between the observation group and the control group （P 〈 0.05） Conclusion Hemodialysis can be used in the clinical treatment of uremia, which can effectively improve and obtain comparatively ideal treatment effect. It is worth popularizing in clinic.