老年2型糖尿病肾病患者血清TGF-β1与IL-18水平变化及临床意义被引量：3

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摘要采用酶联免疫吸附法对39例2型糖尿病患者进行外周血血清TGF-β1、IL-18浓度水平检测以及应用放射性免疫法对尿蛋白排泄率进行测定。结果:(1)DN组TGF-β1、IL-18浓度水平显著高于NDN组和健康对照组(P<0.01);(2)糖尿病组TGF-β1、IL-18浓度水平略高于NDN组和健康对照组(P>0.05);(3)糖尿病组TGF-β1、IL-18浓度水平显著低于DN组(P<0.05);(4)NDN组TGF-β1、IL-18浓度水平稍高于健康对照组(P>0.05);(5)DN组TGF-β1、IL-18浓度水平与UAER值呈明显正相关。结论:细胞因子TGF-β1和IL-18可能均参与了糖尿病肾病的发病。

作者张巧慧李平

机构地区山西省运城市中心医院内分泌科

出处《实用糖尿病杂志》 2015年第6期13-14,共2页 Journal of Practical Diabetology

关键词老年人 2型糖尿病糖尿病肾病 TGF-β1 IL-18 尿蛋白排泄率

分类号 R587.2 [医药卫生—内分泌]

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