黄芪注射液联合化疗对癌症治疗的Meta分析

A Meta-analysis on Astragalus Injection Combined with Chemo-Treatment in Treatment of Advanced Cancer

目的:利用Meta分析方法评价黄芪注射液联合化疗治疗癌症的临床疗效。方法:采用Cochrane循证医学系统评价的方法,全面检索黄芪注射液联合化疗治疗癌症的随机对照试验文献,筛选符合要求的文献进行质量评价,采用Rev Man 5.3专用软件进行统计分析。结果:共有16篇文献符合纳入标准,Jadad评分均低于3分。Meta分析结果表明,黄芪注射液联合化疗与单纯化疗比较,黄芪注射液联合化疗治疗癌症,可提高患者近期疗效有效率和生活质量评分稳定率,并可降低白细胞及血小板下降发生率。但Funnel Plot分析也发现倒漏斗图存在显著不对称,提示存在发表偏倚的可能性。结论:现有的临床证据表明,黄芪注射液联合化疗治疗癌症的疗效优于单纯化疗,并且比单纯化疗更能提高患者近期疗效有效率和生活质量评分稳定率,降低白细胞、血小板及血红蛋白下降发生率。

Objective：To evaluate the effectiveness of Astragalus injection combined with chemotreatment in treatment of cancer using Meta-analysis method. Methods：Randomized controlled trials about Astragalus injection combined with chemotherapy for patient with cancer were searched overall,choosed coincident requirement documents and used Rev Man5.3 to perform data analysis. Results：There were 16 documents were included into the meta analysis and Jadad grade showed that all studies were below three points.The meta analysis showed that compared to chemo-treatment only,the Astragalus injection combined with chemotherapy could enhance the efficient of short- term curative effect and the quality of life and reduce the incidence rate of the drop for WBC,PLT and Hb.But Funnel Plot analysed that Funnel graph appeared obviously unsymmetric,showing that publish bias may be existed. Conclusion：From the existing clinical evidences,Astragalus injection combined with chemo-treatment is more effective than chemotreatment in the treatment of cancer.What＇s more,the Astragalus injection combined with chemotherapy could enhance the efficient of short- term curative effect and the quality of life and reduce the incidence rate of the drop for WBC,PLT and Hb.