产后出血高危因素孕妇在剖宫产术中预防性宫体注射卡前列素氨丁三醇减少产后出血的临床疗效

Effect of Precautionary Uterus Injected Carboprost Tromethamine to Reduce the Postpartum Hemorrhage of Cesarean Section in Pregnant Women with High Risk Factors of Postpartum Hemorrhage

目的探讨剖宫产术中预防性宫体注射卡前列素氨丁三醇减少产后出血的临床疗效。方法将2013年1月~2014年7月我院收治的具有产后出血高危因素的82例行剖宫产产妇纳入研究并按照数字表随机分为两组,各41例,比较两组产后出血及不良反应发生情况。结果观察组术后2h和24h出血量分别为(241.34±18.49)m L和(345.45±23.74)m L,均较对照组明显减少(t=6.84,6.43,P<0.05);观察组术后止血时间和第三产程时间分别为(15.43±3.29)min和(2.87±0.76)min,均较对照组显著缩短(t=8.02,7.29,P<0.05);观察组血红蛋白含量为(104.23±7.33)g·L^(-1),较对照组明显增加(t=7.12,P<0.05);观察组产后出血率、贫血发生率及子宫切除率分别为7.32%、2.44%和0%,均较对照组显著降低(χ~2=9.32,8.84,7.34,P<0.05);两组不良反应均轻微可耐受,且为一过性无需特殊处理可自行消除,其中观察组不良反应发生率为4.88%,显著低于对照组(χ~2=8.78,P<0.05)。结论剖宫产术中预防性宫体注射卡前列素氨丁三醇可有效预防产后出血,且安全性高。

OBJECTIVE To investigate the effect of precautionary uterus injected Carboprost Tromethamine to reduce the postpartum hemorrhage of cesarean section in pregnant women with high risk factors of postpartum hemorrhage. METHODS 82 cases of cesarean section women with risk factors of postpartum hemorrhage in January 2013 to July 2014 in our hospital were included in the study ,they were randomly divided into two groups with 41 cases in each group according the number table methods, postpartum hemorrhage and prevalence of adverse reactions of two groups were compared. RESULTS The amount of bleeding in the observation group at postoperative 2h and 24h volume were （241.34 ± 18.49） mL and （345.45 ± 23.74） mL, significantly reduced than those in the control group （ t = 6.84,6. 43, P 〈 0. 05 ） ; The stop bleeding time and third time of birth process of the observation group were （ 15.43 ± 3.29） rain and （2. 87± 0. 76） min, significantly shortened than these in the control group （t = 8.02,7.29, P 〈0. 05 ）;Hemoglobin content of the observation group was（ 104. 23± 7.33 ）g · L^-1, significantly increased com- pared with the control group （t = 7.12 ,P 〈 0. 05） ;the rate of postpartum hemorrhage, the incidence of anemia and hysterectomy rates of the observation group were 7.32% ,2.44% and 0%, significantly lower than the control group （X2 = 9.32,8.84,7.34, P 〈 0. 05） ;the two group had slight side effects which can be tolerated. And once without special treatment can be eliminated, the incidence of adverse reaction of the observation group was 4.88%, significantly lower than the control group （ x^2 = 8.78, P 〈 0. 05 ）. CONCLUSION Using precautionary uterus injected Carboprost Tromethamine during operation can be effective in preventing postpartum hemorrhage, ？ with high safety, which is suitable for popularization and application.