盐城地区丙型肝炎病毒感染的流行病学特点及基因型分析

Epidemiology of hepatitis C virus infection and its genotype analysis in Yancheng area

目的探讨盐城地区丙型肝炎病毒(HCV)感染的流行病学及基因型特点。方法选取体检者20 185例,抽取空腹静脉血测定其血清丙型肝炎病毒抗体(抗-HCV),统计抗-HCV阳性者的临床资料,并测定患者HCV基因分型及HCV RNA水平,所有患者行B超检查以判断临床预后。结果 HCV总感染率为1.22%,且男性高于女性;随着年龄增长感染率增加。基因1b型占73.17%,经B超检查,6型和1b/2a型所有感染者均仅有肝损伤,基因2a型肝损伤者占80.77%,高于16、3a+3b基因型感染者。结论盐城地区HCV感染以男性及城镇居民为主,且感染率随年龄增加而上升;不同的基因型HCV感染预后不同,可通过基因型分析对患者预后进行评估。

Objective To investigate the characteristics of hepatitis C viurs（HCV）infection and its genotypes in Yancheng area.Methods A total of 20 185 cases of subjects receiving healthy examination were collected,and fasting blood levels of serum antiHCV were detected.Clinical data of patients with HCV infection were statistically analysed.HCV genotypes and levels of HCV RNA were detected,and their clinical prognosis was judged by type-B ultrasonic.Results The total infection rate of HCV was1.22%.The infection rate of male was higher than that of female and the infection rate was increased with the elevation of age.The genotype 1bwas accounted for 73.17%.The results of type-B ultrasonic shown that all patients infected with genotype 6and 1b/2a HCV only had liver damage.80.77% of patients infected with genotype 2aHCV had liver damage,which was higher than that of patients infected with 16 and 3a＋3 bgenotypes.Conclusion Most of HCV infected patients are male,and the infection rate might be increased with the elevation of age.The prognosis is in various different genotypes of HCV,which indicates that the prognosis could be evaluated by genotyping.