血清天门冬氨酸氨基转移酶线粒体同工酶检测在酒精性肝病中的应用价值

Study on the application value of aspartate aminotransferase mitochondrial isoenzyme in patients with alcoholic liver disease

目的分析酒精性肝病患者检测天门冬氨酸氨基转移酶线粒体同工酶(m-AST)的临床价值。方法选取2013年3月至2015年3月在该院肝病科接受诊治的酒精性肝病患者61例(观察组),另选取同期体检健康者61例(对照组),检测其血清m-AST、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)及γ-谷氨酰转移酶(GGT)水平。结果与对照组比较,观察组血清m-AST、ALT、AST及GGT水平均升高,差异均有统计学意义(P<0.05)。酒精性肝病患者中,脂肪肝、肝炎及肝硬化患者治疗后上述各指标差异均有统计学意义(P<0.05)。结论血清m-AST可以同ALT、AST及GGT一起作为临床辅助诊断酒精性肝病的指标,具有一定的临床价值。

Objective To analyse the clinical value of aspartate aminotransferase mitochondrial isoenzyme（m-AST）determination in patients with alcoholic liver disease.Methods 61 cases of patients with alcoholic liver disease（observe group）receiving treatment in this hospital from March 2013 to March 2015 and 61 cases of healthy individuals（control group）were enrolled in this study,and serum levels of m-AST,alanine amino transferase（ALT）,aspartate amino transferase（AST）andγ-glutamyl transferase（GGT）were detected.Results Compared with the control group,serum levels of of m-AST,ALT,AST and GGT were increased in the observe group,there were statistically significant differences（P〈0.05）.In patients with alcoholic liver disease,after treatment,serum levels of m-AST,ALT,AST and GGT were different among patients with hepatic adipose infiltration,patients with hepatitis and patients with liver cirrhosis,there were statistically significant differences（P〈0.05）.Conclusion Combined with ALT,AST and GGT,m-AST could be utilized as an indicator for diagnosing alcoholic liver disease,which has clinical significance.