髋关节置换后凝血纤溶相关指标监测对预防诊断下肢深静脉血栓的临床意义

The clinical significance of monitoring of coagulation and fibrinolysis related indexes after hip replacement for preventing and diagnosing lower extremity deep venous thrombosis

目的评价髋关节置换术后监测D-二聚体、纤维蛋白原及纤维蛋白降解产物对预防诊断下肢深静脉血栓的临床意义。方法选取2013年4月至2015年4月在该院骨科行髋关节置换术的患者66例,其中有下肢深静脉血栓者纳入观察组,无下肢深静脉血栓者纳入对照组,术后均严密监测D-二聚体、纤维蛋白原及纤维蛋白降解产物水平并进行比较分析。结果两组纤维蛋白原及纤维蛋白降解产物水平在各时间点比较,差异均无统计学意义(P>0.05);而D-二聚体水平在各时间点比较,差异均有统计学意义(P<0.05)。结论髋关节置换术后监测D-二聚体、纤维蛋白原及纤维蛋白降解产物对预防诊断下肢深静脉血栓具有一定的临床意义。

Objective To evaluate the clinical significance of monitoring of D-dimer,fibrinogen and fibrin degradation products after hip replacement for diagnosing and preventing the lower extremity deep venous thrombosis.Methods A total of 66 cases of patients who carried out hip replacement from April 2013 to April 2015 in the department of orthopaedic in this hospital were selected.Patients complicated with lower extremity deep venous thrombosis were enrolled into the observation group,while patients without lower extremity deep venous thrombosis were enrolled into the control group.Levels of D-dimer,fibrinogen and fibrin degradation products were strictly monitored after hip replacement and were comparatively analysed.Results There were no statistically significant differences in levels of fibrinogen and fibrin degradation products between the two groups（P〈0.05）,while statistically significant difference was found in level of D-dimer between the two groups（P〉0.05）.Conclusion The monitoring of D-dimer,fibrinogen and fibrin degradation products after hip replacement could have clinical significance for diagnosing and preventing lower extremity deep venous thrombosis.