摘要
特异性识别C-ALL、Null-ALL白血病细胞表面相应抗原的单克隆抗体(CD9、CD10)与具有杀伤细胞的蓖麻毒素偶联制备的免疫毒素在自体骨髓移植中,对残留白血病细胞的清除,预防移植后白血病的复发是有意义的。本实验观察了两组抗人白细胞分化抗原单克隆抗体(CD9、CD10)免疫毒素对白血病细胞(Nalm-6)的清除率。及它们在有效清除白血病细胞剂量范围内对骨髓多向性造血祖细胞、红系和粒单系造血祖细胞增殖的影响。探讨了免疫毒素在骨髓移植中应用的可行性。
Immunotoxin consists of the antibody, which can specifically recognize relative antigen on the surface of leukemic cell, and intact ricin, which kill cell. It is very profitable to eliminate leukemic cell from bone marrow for prophylaxis of leukemia relapse after bone marrow transplantation. In the study, we reported that clongoenic leukemic cell (Nalm-6) were eliminated by two different immunotoxins (with CD9 and CD10). The inhibiting effect of immunotoxins in useful dose on the proliferation of hemopoietic progenitor cells (CFU-mix, BFU-E and CFU-GM) was not obviously.It is probably that immunotoxins will be used in autologous bone marrow transplation.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1991年第5期303-306,共4页
Chinese Journal of Immunology
基金
国家863计划资助项目
关键词
白血病
免疫毒素
造血细胞
Immunotoxin
Leukemic cell
Hemopoietic cell