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Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies

Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies
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摘要 Alzheimer＇s disease（AD）is the most common cause of senile dementia.It is characterized by the formation of plaques mainly composed of the amyloid-beta peptide（Aβ）.Diverse lines of evidence support the notion that accumulation of Aβis a primary cause of AD pathogenesis（Huang and Mucke,2012）.Amyloid precusor protein（APP）processing is dependent on its subcelluar trafficking pathway：Aβis derived from APP by proteolyric processing. Alzheimer＇s disease（AD）is the most common cause of senile dementia.It is characterized by the formation of plaques mainly composed of the amyloid-beta peptide（Aβ）.Diverse lines of evidence support the notion that accumulation of Aβis a primary cause of AD pathogenesis（Huang and Mucke,2012）.Amyloid precusor protein（APP）processing is dependent on its subcelluar trafficking pathway：Aβis derived from APP by proteolyric processing.
作者 Guido Hermey
机构地区 Institute for Molecular and Cellular Cognition
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第11期1727-1728,共2页 中国神经再生研究（英文版）
关键词 APP Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies CS
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献13

  • 1Hermey G (2009) The VpslOp-domain receptor family. Cell Mol Life Sci 66:2677-2689.
  • 2Hermey G, Schmidt N, Bluhm B, Mensching D, Ostermann K, Rupp C, KuhlD, Kins S (2015) SorCSl variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCSlc modulates anterograde APP transport. J Neurochem 135:60-75.
  • 3Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148:1204-1222.
  • 4Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah )A, Small SA, Tanzi RE, Attie AD, Gandy S (2010) Diabetes-associated SorCSl regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorLl and the retromer complex. ) Neurosci 30:13110-13115.
  • 5Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA (2014) Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol 10:443-449.
  • 6Mehmedbasic A, Christensen SK, Nilsson J, Riietschi U, Gustafson C, Poulsen AS, Rasmussen RW, Fjorback AN, Larson G, Andersen OM (2015) SorLA complement-type repeat domains protect the amyloid precursor protein against processing. J Biol Chem 290:3359-3376.
  • 7Nielsen MS, Keat SJ, Hamati JW, Madsen P, Gutzmann J], Engelsberg A, Pedersen KM, Gustafsen C, Nykjaer A, Gliemann J, Nykjaer A, Hermans-Borgmeyer I, Kuhl D, Petersen CM, Hermey G (2008) Different motifs regulate trafficking of SorCSl isoforms. Traffic 9:980-994.
  • 8Oetjen S, Mahlke C, Hermans-Borgmeyer I, Hermey G (2014) Spatiotemporal expression analysis of the growth factor receptor SorCS3. J Comp Neurol 522:3386-3402.
  • 9Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel JP, Hazrati LN, Palotas A, Lan-tigua R, Medrano M, Jimenez-Velazquez I, Vardaranjan B, Simkin I, Haines JL, Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, George-Hyslop PS, Mayeux R (2011) SORCSl alters amyloid precursor protein processing and variants may increase Alzheimer’s disease risk. Ann Neurol 69:47-64.
  • 10Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Cham-ma I, Wang YZ, Zemla R, Lavallee-Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J (2015) The sorting receptor SorCSl regulates trafficking of neurexin and AMPA receptors. Neuron 87:764-780.
Neural Regeneration Research
2015年 第11期

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