白细胞介素28B基因多态性与乙型肝炎的相关性研究进展

Research progress in association between interleukin 28B gene polymorphism and hepatitis B

病毒、环境和宿主因素影响HBV感染后的病程进展、转归和预后。简述了宿主白细胞介素(IL)28B基因多态性与宿主免疫、干扰素抗HBV疗效及HBV感染结局之间存在的某些关联。但目前的研究结果尚未得出一致的结论。认为IL-28B可能通过影响宿主免疫状态而对慢性乙型肝炎(CHB)患者干扰素治疗效果及病毒自发清除产生影响。实验研究前对CHB患者的免疫状态的检测可能有助于研究者得出更为一致的结论。

Hepatitis B virus （HBV） infection seriously threatens human health. Viral, environmental, and host factors can influence the progression, outcome, and prognosis of HBV infection. Accumulating evidence has shown that the host interleukin 28B gene polymorphism is, to a certain degree, associated with host immunity, anti -HBV efficacy of interferon, and HBV infection outcome. However, at present a consistent conclusion has not been reached yet. IL28B may influence the efficacy of interferon therapy and virus spontaneous clearance in patients with chronic hepatitis B （CHB） by affecting the host＇s immune status. Examining the immune status for CHB patients before the ex- perimental study may help researchers to draw a more consistent conclusion.