受体相互作用蛋白3在细胞程序性坏死中的作用

Research Progress of RIP 3 Gene Function and Effectson the Cell Necroptosis

受体相互作用蛋白3(RIP3)是丝氨酸/苏氨酸蛋白激酶家族的一个重要成员,参与炎症反应、免疫应答和死亡诱导进程。关于细胞坏死,经典研究认为是一种不受调控的细胞死亡方式,而最新的RIP3基因功能研究突破了关于细胞坏死的经典观点,认为RIP3通过参与核因子κB、肿瘤坏死因子等分子信号通路,调控细胞的坏死进程(程序性坏死),是细胞坏死与细胞凋亡相互转换的功能开关。该文主要围绕RIP3基因和蛋白结构、信号转导、相互作用网络以及与肿瘤的关系进行综述。

Receptor interacting protein 3 （RIP3）, as an important member of serine/threonine protein kinase family, has the serine/threonine protein kinase activity and is involved in many pathophysiological processes, including inflammation, immune response and cell death induction. Classic viewed cell necrosis as a kind of uncontrolled cell death, which is challenged by the study of RIP3 gene function, discovering that RIP3 is the conversion switch on cell necrosis and apoptosis, and plays a major role in the cell necroptosis, through regulating the nuclear factor-κB and tumor necrosis factor signal pathway. Here is to make a review of RIP3 gene and protein structure,mediating signal transduetion,interaction network and relationship between tumor and RIP 3.