摘要
生存因子Netrin-1在神经和血管的新生过程中均发挥重要作用。最近的研究发现,在胰岛形成过程中,Netrin-1能通过激活整合素调节细胞的迁移、侵袭、增殖和生存,并具有和血管内皮生长因子一样的促进血管生成的功能,刺激平滑肌细胞和内皮细胞有丝分裂。同时,Netrin-1能够在新生的胰岛中表达,并参与调节凋亡,保护胰腺损伤。生存因子Netrin-1对保存胰岛细胞量及修复胰岛功能提供新思路,对2型糖尿病的预防和治疗具有深远的意义。
Netrin-1, a survival factor, plays a major role in the development of neuroganesis and anglogenesis. Recent studies have shown that Netrin-1 transduced through the activation of a6β4 integrin regulating cell migration and invasiveness, cell proliferation during islet formation. Netrin-1 is also involved in promoting angiogenesis like vascular endothelial growth factor, stimulating mitogenesis of vascular smooth muscle and endothelial cell lines. At the same time, Netrin-1 can activate islet neogenesis, modulate cell apoptosis and protect the pancreas from injury. Survival factor Netrin-1 has significant role in preserving islet mass and repairing pancreatic cells, which provides a novel avenue for prevention and treatment of type 2 diabetes mellitus.
出处
《医学综述》
2015年第23期4236-4239,共4页
Medical Recapitulate
基金
国家自然科学基金(81200594)
南京市医学科技发展项目(ZKX14037)
