JAK-STAT信号通路和心肌葡萄糖代谢

JAK-STAT Signaling Pathway and Myocardial Glucose Metabolism

葡萄糖是心肌的重要能源物质之一,葡萄糖转运及代谢是心脏进行各项生物学活动的基础。Janus激酶-信号转导和转录通路(JAK-STAT)是一条由多种细胞因子参与的信号转导通路,几乎存在于机体的所有组织中。该文总结关于心肌葡萄糖代谢与JAK-STAT信号通路关系的文献发现,JAK-STAT信号转导通路通过多种方式参与胰岛素诱导的心肌葡萄糖代谢。

Glucose is one of the most important energy sources of myocardium, and glucose transport and metabolism are the basic biological activities in heart. Janus kinase-signal transducer and activator of transcription （JAK-STAT） is a signal transduction pathway involving a variety of cytokines, which has been found in almost every tissue of body. Here is to make a review of the existing discoveries on myocardial glucose metabolism and JAK-STAT,and it＇s found that JAK-STAT is involved in insulin induced myocardial glucose metabolism through multiple manners.