TNF-α、PARP及施万细胞凋亡在糖尿病痛性周围神经病变中的作用

The Effect of TNF-α,PARP and Schwann Cell Apoptosis in Diabetic Painful Neuropathy

糖尿病周围神经病变的发病机制复杂,为多种综合性因素参与。近年来,氧化应激导致的周围神经病变一直是大家关注的热点,而施万细胞凋亡导致的糖尿病周围神经病变研究甚少。肿瘤坏死因子α(TNF-α)及多聚腺苷二磷酸核糖合成酶(PARP)参与了血旺细胞凋亡的发生,均在糖尿病周围神经病变中发挥了重要作用。现就TNF-α、PARP与施万细胞凋亡的相关性及在糖尿病周围神经病变中的作用予以综述。

The pathogenesis of diabetic peripheral neuropathy is complex, which involves a variety of factors. In recent years, oxidative stress caused peripheral neuropathy has been the focus of attention, but the research on Schwann cells apoptosis resulted peripheral neuropathy in diabetes is rarely seen. Tumor necrosis factor α （TNF-α） and poly（ ADP-ribese ） polymerase （PARP） are involved in the pathogenesis of Schwann cell apoptosis,playing an important role in diabetic peripheral neuropathy. Here is to make a review of the correlation between TNF-α, PARP and Schwann cell apoptosis in diabetic peripheral neuropathy.