丹红注射液联合甲钴胺治疗老年糖尿病周围神经病变的疗效分析

The Adverse Reactions and Efficacy Analysis of Danhong Injection Combined with Mecobalamin in Elderly Patients with Diabetic Peripheral Neuropathy

目的探讨丹红注射液联合甲钴胺治疗老年糖尿病周围神经病变的不良反应及疗效。方法选择2014年1月至2015年1月武装警察部队总医院接诊的老年糖尿病患者80例作为研究对象。采用随机数字表法,将80例患者分为观察组和对照组,各40例。观察组采用40 m L丹红注射液联合2 mg甲钴胺进行治疗,对照组采用2 mg甲钴胺进行治疗。对比分析两组患者治疗后症状改善情况、神经传导速度、不良反应发生情况和疗效情况。结果观察组四肢感觉好转率、腱反射恢复率、排尿障碍减轻率显著高于对照组[72.5%(29/40)比25.0%(10/40),40.0%(16/40)比7.5%(3/40),42.5%(17/40)比12.5%(5/40)],四肢温度低发生率显著低于对照组[2.5%(1/40)比75.0%(30/40)],差异有统计学意义(P<0.05)。治疗后观察组运动神经传导速度正中神经、腓神经显著高于对照组[(51.8±4.3)m/s比(45.3±3.8)m/s,(43.3±4.6)m/s比(38.3±4.0)m/s],感觉神经传导速度正中神经、腓神经均显著高于对照组[(45.0±4.1)m/s比(40.9±3.8)m/s,(43.0±3.6)m/s比(36.1±3.5)m/s],差异有统计学意义(P<0.01)。观察组总有效率为92.5%(37/40),对照组总有效率为75.0%(30/40),两组患者疗效比较差异有统计学意义(P<0.05)。观察组不良反应发生率7.5%(3/40),对照组患者不良反应发生率为12.5%(5/40)。两组患者治疗后不良反应发生率比较差异无统计学意义(P>0.05)。结论丹红注射液联合甲钴胺治疗对老年糖尿病周围神经病变的效果良好,不良反应少且低,明显优于仅仅使用甲钴胺进行治疗,值得在医学中广泛应用并临床推广。

Objective To study the effect and adverse effects of Danhoug injection combined with mecobalamin in the elderly diabetic peripheral neuropathy. Methods A total of 80 elderly patients with diabetes in Armed Police General Hospital from Jan. 2014 to Jan. 2015 were included. They were divided into observa- tion and control group according to random number table method ,40 cases each. The control group was treated with 2 mg of mecobalamin only, while the observation group was treated with the 40 mL Danhong injection combined with 2 mg methylcobalamin. Symptoms improvement after treatment, nerve conduction velocity, adverse reactions and therapeutic effect were compared between the two groups. Results Limbs feeling bet- ter, tendon reflex recovery, voiding dysfunction mitigation rate in the observation group were significant higher than the control group[72.5% （29/40） vs 25.0% （10/40） ,40.0% （16/40） vs 7.5% （3/40） ,42.5% （17/40） vs 12.5% （5/40）], low-temperature limbs in the observation group was significantly lower than the control group [2.5% （ 1/40 ） vs 75.0% （ 30/40 ） ] （ P 〈 0. 05 ）. After treatment motor nerve median nerve and peroneal nerve of the observation group was significantly higher than the control group[ （51.8 ± 4. 3 ） rn/s vs （45.3 ± 3. 8 ） m/s, （43.3 ± 4.6 ） m/s vs （ 38.3 ±4. 0） m/s ], median nerve and sural sensory nerves of the observation group was significantly higher than the control group [ （45.0 ± 4. 1 ） m/s vs （40.9 ±3.8） m/s,（43.0±3.6） m/s vs （36.1±3.5） m/s],with significant difference （P〈0.01）. Total effective rate of the observation group was 92.5 % （37/40） , of the control group was 75.0% （30/40）, the difference was statistically significant （ P 〈 0.05 ）. Adverse reaction rate in the observation group after treatment was 7.5% （3/40） ,in the control group was 12. 5% （5/40） ,the difference was not statistically significant（P 〉 0. 05 ）. Conclusion The effect of Danhong injection combined with mecobalamin on elderly patients with diabetic peripheral neuropathy is good, with few adverse reactions, which is significantly better than the effect of mecobalamin only and worthy of wide application and promotion in clinical.