根除幽门螺杆菌治疗与功能性消化不良症状的关系

Correlation between Eradication of Helicobacter Pylori and Functional Dyspepsia

目的研究根除幽门螺杆菌(Hp)治疗与功能性消化不良症状的关系。方法选取2013年1月至2014年7月隆昌县人民医院收治的功能性消化不良患者356例为研究对象,按照随机数字表法分为观察组和对照组,各178例。观察组给予Hp根除及药物治疗,对照组仅予以促进胃肠动力、解痉等治疗。比较两组患者治疗后的Hp根除率、临床疗效、症状积分及药物不良反应发生情况。结果观察组各症状积分均明显低于对照组(P<0.05),症状总得分分别为(1.29±0.41)分、(3.95±1.20)分,差异有统计学意义(P<0.05)。观察组Hp根除率为88.4%,高于对照组的31.5%(P<0.05)。治疗后Hp根除组各症状得分均明显低于Hp未根除组,症状总得分分别为(1.17±0.38)分、(4.01±1.25)分,差异有统计学意义(P<0.05)。观察组药物不良反应发生率为5.6%,对照组为3.4%,差异无统计学意义(P>0.05)。结论 Hp感染可加重患者消化系统症状,治疗方案中联合根除Hp治疗可明显改善患者上腹部症状,提高功能性消化不良患者的临床疗效,且安全性高,有利于提高治疗效果。

Objective To study the effect of Helicobacter pylori （Hp） eradication and functional dyspepsia. Methods Total of 356 patients with functional dyspepsia admitted to Longchang County People＇s Hospital from Jan. 2013 to Jul. 2014 were randomly divided into observation group and control group, 178 cases in each group. The observation group was given Hp eradication and drug treatment, the control group was only given gastrointestinal motility promoting treatment and antispasmodic treatment. Eradication rate, clinical efficacy, symptom score and adverse drug reactions of the two groups after treatment were compared. Results The symptom scores of the observation group were significantly lower than that of the control group （P 〈 0. 05 ）, the total symptom scores were （ 1.29 ± 0. 41 ） and （3.95 ±1.20） ,the difference was statistically significant（ P 〈 0. 05 ）. The eradication rate of Hp in the observation group was 88.4%, of the control group was 31.5%. After treatment symptom scores of Hp eradication group were significantly lower than those of the non-eradication group, the total symptom scores were （ 1.17 ± 0. 38 ） and （4. 01± 1.25 ）, the difference was statistically significant（ P 〈 0.05 ）. The incidence of adverse drug reactions in the observation group was 5.6%, of the control group was 3.4%, the difference was not statistically significant （P 〉 0.05 ）. Conclusion Hp infection can aggravate the symptoms of digestive system, and the treatment of Hp can significantly improve the patients with abdominal symptoms, improve the clinical efficacy of functional dyspepsia patients, with high safety, thus is beneficial to improve the treatment effect.