大肠癌患者化疗前后证素变化的初步探讨

Colorectal Cancer before and after Chemotherapy in Patients with Syndrome Elements Change of Preliminary Discussion

目的观察大肠癌患者奥沙利铂化疗前后过程中证素演变的特点,为中西医联合用药提供参考方案。方法采集48例接受奥沙利铂化疗的大肠癌患者的四诊信息,运用证素辨证法提取证素,观察化疗前后临床症状、证素变化情况。结果 48例患者化疗后手足麻木、疲乏、食欲减退、恶心呕吐发生频率增加(P<0.05),化疗后病性证素阴虚、血虚、气虚和病位证素脾、肾频数显著增加(P<0.05)。结论大肠癌患者在化疗过程中证素会发生变化,主要是因化疗药物损伤气、血、津液等而引起以虚证为主的变化。

Objective To observe the characteristics of evolution of syndrome elements of oxaliplatin in patients with colorectal cancer before and after chemotherapy in the process, and the therapy of traditional Chinese medicine and Western medicine to provide reference. Methods Collect 48 colorectal cancer patients received oxaliplatin hemotherapy with TCM diagnostic information, use syndrome elements differentiation to get the syndrome elements, observe the clinical symptoms and the changes of syndrome elements before and after chemotherapy. Results 48 cases of numbness, fatigue, loss of appetite decline in patients after chemotherapy, nausea and vomit an increase in the frequency of occurrence （P〈0.05）, chemotherapy after disease of syndrome elements of yin deficiency, blood deficiency, Qi deficiency and disease syndrome spleen and kidney frequency significantly increased （P〈0.05）. Conclusion The change of syndrome elements in patients with of colorectal cancer during chemotherapy, the main reason is the hemotherapy drugs on the human body, qi, blood and fluid damage, in which is the main cause of deficiency syndrome.