新加达原饮治疗慢性乙型肝炎的临床研究

Clinical Research of Xinjia Dayuan Decotion on Chronic Hepatitis B

目的观察新加达原饮治疗慢性乙型肝炎(CHB)的临床疗效。方法 20例患者均给予新加达原饮治疗,疗程12周,比较治疗前、治疗后4、8、12周时患者肝功能,HBe Ag及HBV-DNA变化情况,分析ALT、HBe Ag及HBV-DNA的关系。结果与治疗前比较,患者ALT于治疗后8周时显著升高(P<0.01),12周时明显下降(P<0.01);HBe Ag及HBV-DNA水平持续下降,治疗12周时下降最显著(P<0.01)。结论新加达原饮能快速降低慢性乙型肝炎患者HBe Ag及HBV-DNA的水平,根据治疗后患者ALT,HBV-DNA及HBe Ag变化曲线不同,推测新加达原饮抗乙型肝炎病毒的机制可能是通过激发机体免疫应答完成的。

Objective To observe the clinical effects of treatment of Xinjia Dayuan decotion on chronic hepatitis B. Methods 20 patients with CHB were treated with Xinjia Dayuan decotion for 12 weeks. Compared the ALT, HBeAg and HBV-DNA of patients before treatment with 4, 8, 12 weeks of treatment, and analyzed the relationship of them. Results Compared with pre-treatment, the levels of ALT were rised after treatment, significantly at week 8 treatment （P〈0.01）, were significantly decreased at week 12 treatment （P〈0.01）; The levels of HBeAg and HBV DNA were decreased after treatment, significantly decreased at week 12 treatment （P〈0.01）. Conclusion Xinjia Dayuan decotion could reduce the levels of HBeAg and HBV DNA in patients with CHB quickly. According to the difference on the changing track between the ALT, HBV DNA and HBeAg of patients after treatment, we speculated that the antiviral mechanism about Xinjia Dayuan decotion may be done by stimulating the body＇s immune response.