益气消癥方对慢性阻塞性肺疾病稳定期患者肺功能和血流变的影响

Influence of Yiqi Xiaozheng Formula on pulmonary function and blood rheology of patients with chronic obstructive pulmonary disease in stable period

目的:从肺功能和血流变两方面,评价益气消癥方对慢性阻塞性肺疾病(COPD)稳定期患者的治疗作用,并探讨其作用机制。方法:选择COPD稳定期患者46例,随机分为中药组23例、对照组23例。对照组给予西医常规治疗,中药组在此基础上加用益气消癥方,治疗8周后,比较治疗前后及两组间肺功能和血流变的变化。结果:中药组和对照组各剔除、脱落3例。治疗前两组基线资料具有可比性。肺功能方面,中药组FEF50、FEF75、MMEF75/25升高幅度均明显高于对照组(P<0.05),且中药组MMEF75/25较治疗前有明显升高(P<0.05)。中药组血流变各项指标较对照组均有明显降低(P<0.05)。结论:西医常规治疗基础上加用益气消癥方,能够在一定程度上改善COPD稳定期患者肺功能、血流变指标。

Objective： To evaluate the therapeutic effect of Yiqi Xiaozheng Formula on patients with chronic obstructive pulmonary disease（COPD） in stable period from the pulmonary function and blood rheology, and to explore its action mechanism. Methods： 46 cases of patients with stable COPD were selected and randomly divided into Chinese medicine group（23 cases） and control group（23 cases）. Patients in control group were treated with western medicine routine treatment and patients in Chinese medicine group were treated with Yiqi Xiaozheng Formula. After treating for 8 weeks, the pulmonary function and blood rheology of patients in the two groups before and after treatment were compared. Results： 3 cases in each group were rejected or dropped out. The baseline data of the two groups before treatment was comparable. The FEF50, FEF75 and MMEF75/25 of patients in Chinese medicine group was significantly higher than that of control group（P〈0.05）, and the MMEF75/25 of patients in Chinese medicine group was increased significantly compared with treatment before（P〈0.05）. The indicators of blood rheology of patients in Chinese medicine group were lower than that of control group（P〈0.05）. Conclusion： Yiqi Xiaozheng Formula based on the western medicine routine treatment could improve the pulmonary function and indicators of blood rheology of COPD patients to some extent.