中药治疗自身免疫性肝炎的实验研究进展

Experimental research progress on treating autoimmune hepatitis with Chinese materia medica

自身免疫性肝炎是一类以自身免疫反应为基础,以高丙种球蛋白血症为特征的肝脏炎性病变。中医药诊治肝病历史悠久,诊疗体系完整,方法众多。文章分别从中药复方和单味中药就近年来中药治疗自身免疫性肝炎的实验研究进展做一综述。其中,中药复方治疗自身免疫性肝炎的实验研究主要分为健脾疏肝类、滋补肝肾类、清热利湿类,在单味中药的实验研究中,黄芪、苦参、丹参、白芍、冬虫夏草、三七等中药的研究较多,在肝功能、氧化应激、炎性介质的释放、肝脏炎性细胞浸润的改善中,复方和单味中药的药效都有较好的体现。

Autoimmune hepatitis is a liver inflammatory disease that is based on autoimmune responses and characterized as hypergammaglobulinemia. Traditional Chinese medicine has a long history of treating liver diseases, and also possesses a complete system of diagnosis and treatment. This article summarized the experimental research progress on treating autoimmune hepatitis with Chinese herbal compound prescriptions and single Chinese herbs in recent years. The Chinese herbal compound prescriptions applied in treating autoimmune hepatitis could be divided into the following categories as dispersing stagnated liver qi and strengthening spleen, nourishing liver and kidney and clearing heat and promoting dieresis, and the single Chinese herbs commonly applied in treating autoimmune hepatitis were milkvetch root, lightyellow sophora root, danshen root, debark peony root, Chinese caterpillar fungus, sanqi and so on. The improving effect of Chinese herbal compound prescriptions and single Chinese herbs on the liver function, oxidative stress, release of inl ammatory factors and inl ammatory cells ini ltrating in the liver parenchyma was good.