小剂量盐酸普萘洛尔联合平阳霉素治疗婴幼儿血管瘤的疗效观察

Effect of Propranolol hydrochloride combined with Bleomycin A5 on treating patients with infantile hemangioma

目的观察小剂量盐酸普萘洛尔口服联合平阳霉素局部注射治疗婴幼儿血管瘤临床疗效，对比单纯口服盐酸普萘洛尔治疗婴幼儿血管瘤的疗效差别。方法选取自2012年1月至2013年12月治疗的婴幼儿血管瘤患儿160例，随机分为实验组（n=80）和对照组（n=80），实验组在予以盐酸普萘洛尔1mg／d口服的同时，每月1次局部注射平阳霉素治疗；对照组单纯予以盐酸普萘洛尔1mg／d口服治疗。两组患儿均每月来院复诊，观察两组患儿血管瘤颜色、大小、质地、表皮温度及超声下血流信号变化，评价临床效果。结果盐酸普萘洛尔联合平阳霉素注射治疗效果优于单纯口服药物治疗，血管瘤吸收快，治疗时间短，在相同的时间内临床治愈率高，组间差异具有统计学意义。结论盐酸普萘洛尔口服联合平阳霉素注射治疗婴幼儿血管瘤，可有效控制瘤体增长，促进血管瘤短期萎缩吸收，控制病情反复进展，减少治疗周期，联合用药效果明显优于单纯口服药物治疗。

Objective To investigate the clinical effect of small-dose Propranolol hydrochloride combined with Bleomycin A5 for the treatment of patients with infantile hemangioma, and compare the effects between combined administration and only oral Propranolol Hydrochloride. Methods From Jan. 2012 to Dec. 2013, 160 patients with infantile hemangioma in our hospital were randomly divided into two groups： the experience group （ n = 80）, which received oral administration of Propranolol hydrochloride （1 mg/d） and local injection of Bleomycin A5 per month ; the control group （ n = 80）, which only received oral administration of Propranolol hydrochloride （1 mg/d）. Return visit was performed monthly to determine the color, size, texture, epidermic temperature and changes of blood flow signal of hemangioma under ultrasound. Results Propranolol hydrochloride combined with Bleomycin A5 was superior to oral administration in treating hemangioma with these advantages, like swift absorption of hemangioma, short treatment time and high response rates （ P 〈 0.05）. Conclusion Propranolol hydrochloride combined with Bleomycin A5 is superior to single Propranolol hydrochloride in treatment infantile hemangioma through contributing to the short-term absorption and effective controlling of tumor size and reducing the treatment time.