双抗血小板方案对低危冠心病患者药物洗脱支架术后的影响

Double antiplatelet scheme for patients with coronary heart disease of low risk after drug-eluting stent

目的 探析双抗血小板方案对低危冠心病患者药物洗脱支架术后的影响.方法 以我院2012年1月至2014年6月收治的行DES术的87例冠心病患者作为研究对象,随机分为观察组（n=44）与对照组（n=43）.对照组于DES术后采取单抗血小板方案,观察组采取双抗血小板方案,比较治疗有效率、支架内血栓发生率、心血管意外事件发生率及不良反应发生率.结果 观察组治疗有效率90.9％（40/44）,高于对照组的74.4％（32/43）,差异有统计学意义（P＜0.05）.观察组支架内血栓发生率为2.3％（1/44）,不良反应发生率为9.1％（4/44）,对照组分别为4.7％ （2/43）、4.7％（2/43）,差异无统计学意义（P＞0.05）;观察组心血管意外事件发生率为2.3％（1/44）,对照组为14.0％（6/43）,差异有统计学意义（P＜0.05）.结论 在低危冠心病患者药物洗脱支架（DES）术后应用双抗血小板方案可有效强化手术效果,且减少术后心血管意外事件,安全可靠,值得借鉴与应用.

Objective To explore the effect of double antiplatelet scheme for patients with coronary heart disease of low risk after drug-eluting stent （DES）.Methods 87 patients with coronary heart disease undergoing DES at our hospital from January,2012 to June,2014 were selected as study objects and were randomly divided into an observation group （n=44） and a control group （n=43）.The control group were treated with platelet monoclonal antibody after DES and the observation group with double antiplatelet scheme.The efficacy and the incidences of stent thrombosis,cardiovascular accidents,and adverse reactions were compared between these two groups.Results The efficacy was 90.9％ （40/44） in the observation group and was 74.4％ （32/43） in the control group,with a statistical difference （P＜0.05）.The incidences of stent thrombosis,cardiovascular accidents,and adverse reactions were 2.3％ （1/44）,2.3％ （1/44）,and 9.1％ （4/44） in the observation group and 4.7％ （2/43）,14.0％ （6/43）,and 4.7％ （2/43） in the control group,with a statistical difference in the incidence of cardiovascular accidents （P＜0.05）.Conclusions Double antiplatelet scheme for patients with coronary heart disease of low risk after drug-eluting stent can effectively strengthen the effect of surgery and reduce postoperative cardiovascular accidents and is safe,reliable,and worth being learnt and applied.