胺碘酮在慢性心力衰竭并发心律失常患者中的应用效果

Amiodarone for patients with chronic heart failure complicated with arrhythmia

目的 探讨在临床常规对症治疗基础上加以胺碘酮干预对慢性心力衰竭并发心律失常患者的临床疗效.方法 收集我院2012年8月至2015年3月收治的慢性心力衰竭并发心律失常患者78例进行前瞻性研究,将其随机分为对照组与实验组,每组39例.对照组常规对症治疗,实验组在对照组的基础上口服胺碘酮片.比较两组左心射血分数、6分钟步行距离、心律失常治疗效果与药物不良反应等.结果 治疗后,两组LEEF与6MWT水平比较,差异有统计学意义（P＜0.01）;实验组心律失常治疗效果显著优于对照组,差异有统计学意义（P＜0.01）;两组药物不良反应发生率差异无统计学意义（P＞0.05）.结论 在临床常规对症治疗基础上加以胺碘酮干预对慢性心力衰竭并发心律失常患者的临床疗效显著,具有借鉴性.

Objective To investigate the clinical curative effect of amiodarone basing on conventional clinical symptomatic treatment for patients with chronic heart failure complicated with arrhythmia.Methods 78 patients with chronic heart failure complicated with arrhythmia admitted into our hospital from August,2012 to March,2015 were selected for prospective study and were randomly divided into a control group and an experimental group,39 cases for each group.The control group were given conventional symptomatic treatment;in addition,the experimental group orally took amiodarone tablets.The left ventricular ejection fraction （LVEF）,6-minute walk distance（6MWT）,treatment effect of arrhythmia,incidence of adverse drug reactions were compared between these two groups.Results After the treatment,there were statistical differences in LVEF and 6MWT （P＜0.01） but no in the incidence of adverse drug reactions （P＜ 0.05） between these two groups.The curative effect of cardiac arrhythmia was significantly better in the experimental group than in the control group （P＜0.01）.Conclusion Amiodarone basing on conventional clinical symptomatic treatment for patients with chronic heart failure complicated with arrhythmia is significantly effective and has reference value.