不同治疗剂量的齐拉西酮对精神分裂症患者脑电图的影响

Effects of Different Doses of Ziprasidone on EEG in the Treatment of Schizophrenic Patients

【目的】研究不同剂量齐拉西酮对精神分裂症患者脑电图的影响。【方法】根据不同给药剂量将180例精神分裂症患者分为三组：低剂量组、中剂量组、高剂量组，每组各60例。其中低剂量组给予齐拉西酮＜40 m g／d ，平均（241．±40．） mg／d。中剂量组给予齐拉西酮40～100 mg／d ，平均（685．±100．）mg／d。高剂量组给予齐拉西酮100～160 m g／d ，平均（1114．±223．） m g／d。于治疗后1个月、3个月进行脑电图检测。【结果】治疗前各组患者脑电图检查显示正常。治疗1个月后，低剂量组脑电图轻度异常者17例，中度异常者2例，重度异常者0例；中剂量组轻度异常者12例，中度异常者18例，重度异常者0例，高剂量组轻度异常者10例，中度异常者29例，重度异常者0例，各组间比较，差异具有统计学意义（均 P ＜00．5）。治疗3个月后各组脑电图异常者较治疗1个月明显加重，其差异均有统计学意义（均 P ＜00．5），即随着治疗剂量和时间是增加，脑电图异常发生率及其异常程度增高。【结论】高剂量齐拉西酮比低剂量更为容易导致患者脑电图异常，且齐拉西酮剂量越大，脑电图异常程度越严重。

Objective]To study the brain electrical activity changes of Patients with schizophrenia in different ziprasidone treatment doses .[Methods]180 cases of schizophrenia were divided into 3 groups according to the dif‐ferent doses ：low dose group of 60 cases ,middle dose group of 60 cases ,high dose group of 60 cases .The low dose group was given ziprasidone of 〈 40 mg/d ,with the average of （24 1. ± 4 0.） mg/d .The middle dose group for ziprasidone of 40-100 mg/d ,with the average of （68 5. ± 10 0.） mg/d .The high dose group for ziprasidone of 100-160 mg/d ,with the average of （111 4. ± 22 3.） mg/d .In 1 month ,3 months after treatment ,EEG was de‐tected in different ziprasidone treatment doses respectively .[Results]The EEG of the patients before treatment showed normal 1. month after treatment ,the light abnormal were 17 cases ,medium abnormal 2 cases ,severe ab‐normal 0 in the low dose group ;the light abnormal were 12 cases ,medium abnormal 18 cases ,severe abnormal 0 in the middle dose group ;the light abnormal were 10 cases ,medium abnormal 29 cases ,severe abnormal 0 in the high dose group .comparison among different degree ,the difference was statistically significant （ P 〈0 0.5） .After 3 months treatment ,the abnormal EEG in each group was significantly worse than that 1 month before the treat‐ment ,the difference was statistically significant （ P 〈0 0.5） ,that was ,with the dose and duration of treatment , the abnormal rate of EEG and the abnormal degree increased [.Conclusion]High dose of ziprasidone is more prone to EEG abnormality than low dose ,and the bigger ziprasidone dose ,the heavier the degree of abnormal EEG is .