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LncRNA在胰岛β细胞功能失调中的研究进展

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摘要 长链非编码RNA(10ngnon-codingRNA,in—cRNA)是一类转录本长度超过200个核苷酸的非编码RNA,因缺乏完整的开放阅读框而不能编码蛋白质。在人类基因组中,lncRNA在表观遗传学调控、转录调控和转录后调控等方面发挥着重要作用,是继microRNA之后的又一研究热点。糖尿病(dia-betesmellitus,DM)是一种复杂的代谢性疾病,β细胞破坏和这些胰岛素分泌细胞不能代偿性补充胰岛素的需求增加导致葡萄糖稳态失衡。
出处 《医学临床研究》 CAS 2015年第11期2221-2224,共4页 Journal of Clinical Research
基金 国家自然科学基金(编号:81200593)
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